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How do cannabinoids in transdermal patches affect the circulation and blood flow in the skin at the application site?

How do cannabinoids in transdermal patches affect the circulation and blood flow in the skin at the application site? Cannabinoids, particularly CBD, have been shown to influence blood flow by interacting with CB2 receptors on vascular tissues, potentially promoting vasodilation and improving circulation. Increased blood flow at the application site could enhance cannabinoid absorption by delivering more cannabinoids into the bloodstream. On the other hand, excessive vasodilation may cause discomfort or skin irritation. Cannabinoid patches may need to be designed to modulate these effects for optimal therapeutic outcomes while minimizing adverse reactions.

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