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How do different skin thicknesses across the body impact the transdermal absorption of cannabinoids in patches?

How do different skin thicknesses across the body impact the transdermal absorption of cannabinoids in patches? Different skin thicknesses across the body impact cannabinoid absorption, as thicker skin layers (such as on the palms and soles) present more resistance to penetration than thinner skin (like on the inner forearm). Thicker skin may require higher concentrations of cannabinoids or additional enhancers to facilitate absorption. For areas with thinner skin, cannabinoids can penetrate more easily, requiring careful dosage adjustments to prevent over-delivery. Patch designs can be optimized by targeting specific areas of the body, taking into account the skin's thickness for more efficient cannabinoid delivery.

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