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How do factors like humidity, temperature, and physical activity affect the efficiency of cannabinoid delivery through transdermal patches?

How do factors like humidity, temperature, and physical activity affect the efficiency of cannabinoid delivery through transdermal patches? Humidity and temperature can influence the skin’s permeability, with increased humidity and higher temperatures generally enhancing cannabinoid absorption by softening the skin. Physical activity increases circulation, which can accelerate the diffusion of cannabinoids through the skin, leading to faster onset of effects. However, excessive sweating or movement may reduce patch adhesion, impacting consistent delivery. These environmental factors should be considered in patch design to ensure stable and efficient cannabinoid release in varying conditions.

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