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How do the chemical properties of cannabinoids, such as their hydrophobicity or hydrophilicity, influence their effectiveness in patch formulations?

How do the chemical properties of cannabinoids, such as their hydrophobicity or hydrophilicity, influence their effectiveness in patch formulations? The hydrophobic or hydrophilic nature of cannabinoids significantly impacts their solubility and absorption through the skin in patch formulations. Hydrophobic cannabinoids, like CBD, require carrier oils or lipid-based formulations to enhance solubility and facilitate deeper penetration into the skin layers. Hydrophilic cannabinoids, on the other hand, are better suited to water-based formulations. Understanding these chemical properties is crucial for optimizing the delivery and bioavailability of cannabinoids in transdermal patches.

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