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How do transdermal cannabinoid patches compare to oral administration in terms of onset time and peak plasma concentrations for cannabinoids like CBG and CBN?

How do transdermal cannabinoid patches compare to oral administration in terms of onset time and peak plasma concentrations for cannabinoids like CBG and CBN? Transdermal cannabinoid patches provide a slower, more controlled release of cannabinoids compared to oral administration, leading to a more gradual onset of effects. Oral administration typically leads to faster initial absorption but may result in more variability in peak plasma concentrations due to the first-pass effect in the liver. With transdermal delivery, cannabinoids like CBG and CBN bypass the gastrointestinal tract, resulting in steadier and more predictable plasma levels. This controlled delivery can be advantageous for conditions requiring sustained relief.

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