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How does the particle size of cannabinoids in patch formulations impact skin absorption and the duration of therapeutic effects?

How does the particle size of cannabinoids in patch formulations impact skin absorption and the duration of therapeutic effects? The particle size of cannabinoids in patch formulations plays a crucial role in their absorption through the skin. Smaller particles have a larger surface area, allowing for better penetration into the skin layers and faster absorption, leading to more rapid onset of therapeutic effects. Larger particles may have slower absorption rates, providing a longer duration of action. The balance of particle size can be optimized depending on the desired therapeutic goals, whether it is quick relief or prolonged effects.

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