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What impact does the method of consumption (e.g., smoking, vaping, edibles) have on cannabinoid efficacy and safety?

What impact does the method of consumption (e.g., smoking, vaping, edibles) have on cannabinoid efficacy and safety? The method of consumption significantly impacts cannabinoid efficacy and safety due to variations in absorption, onset of effects, and potential health risks. Inhalation methods, such as smoking or vaping, provide rapid onset of effects but may carry risks related to respiratory health. Conversely, edibles have delayed onset and longer-lasting effects, which can lead to dosing errors if patients are unaware of the time it takes for effects to manifest. Each method also has different bioavailability, influencing the amount of active compounds that reach the bloodstream. Understanding these differences is crucial for guiding patients in choosing appropriate consumption methods to optimize therapeutic outcomes while minimizing potential risks (Wilkinson et al., 2020).
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