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What impact does the molecular weight of cannabinoids like CBG and CBN have on their ability to penetrate the skin when delivered via patches?

What impact does the molecular weight of cannabinoids like CBG and CBN have on their ability to penetrate the skin when delivered via patches? The molecular weight of cannabinoids like CBG and CBN affects their ability to penetrate the skin by influencing their diffusion rate through the epidermis. Larger molecules generally have a harder time penetrating the skin barrier, which can result in slower absorption and a reduced therapeutic effect. CBG and CBN, with slightly higher molecular weights than CBD, may require enhanced delivery systems or the use of penetration enhancers to optimize their absorption. Formulation adjustments, such as using microemulsions or liposomes, can improve the delivery of these larger cannabinoids.

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