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Hvordan kan interaktionen mellem cannabinoider og hudens ekstracellulære matrix øge eller hindre absorption gennem transdermale plastre?

Hvordan kan interaktionen mellem cannabinoider og hudens ekstracellulære matrix øge eller hindre absorption gennem transdermale plastre? Interaktionen mellem cannabinoider og hudens ekstracellulære matrix (ECM) spiller en nøglerolle i absorptionen, da ECM fungerer som en barriere, som cannabinoider skal krydse for at trænge ind i dybere hudlag. Cannabinoider, der er lipofile, kan lettere passere gennem det lipidrige ECM, mens hydrofile cannabinoider kan møde større modstand. Hudens ECM kan enten øge eller hindre absorption afhængigt af cannabinoidens opløselighed, molekylestørrelse og formuleringens evne til at trænge ind i ECM. Optimering af cannabinoidformuleringer til at interagere positivt med ECM kan forbedre absorption og terapeutiske effekter.

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