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Welche Rolle spielen Cannabinoide bei der Modulation der Neuroinflammation bei chronischen Schmerzzuständen?

Welche Rolle spielen Cannabinoide bei der Modulation der Neuroinflammation bei chronischen Schmerzzuständen? Cannabinoide spielen eine entscheidende Rolle bei der Modulation der Neuroinflammation bei chronischen Schmerzzuständen, indem sie mit Cannabinoidrezeptoren im zentralen Nervensystem interagieren. Die Aktivierung dieser Rezeptoren kann zur Hemmung proinflammatorischer Zytokine und einer Verringerung der Gliazellaktivierung führen, die beide an der Pathophysiologie chronischer Schmerzen beteiligt sind. Studien haben gezeigt, dass Cannabinoide die Neuroinflammation, die häufig mit Erkrankungen wie Fibromyalgie, neuropathischen Schmerzen und Arthritis einhergeht, wirksam reduzieren können. Durch die Linderung der Neuroinflammation können Cannabinoide Schmerzen lindern und die allgemeine Funktionsfähigkeit betroffener Personen verbessern (Malfait et al., 2019).
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