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Kako THC i CBD međusobno djeluju u reguliranju neuronske ekscitabilnosti tijekom napadaja?

Kako THC i CBD međusobno djeluju u reguliranju neuronske ekscitabilnosti tijekom napadaja? THC i CBD međusobno djeluju kako bi regulirali neuronsku ekscitabilnost utječući na različite receptore i putove u mozgu, nudeći potencijalni terapeutski pristup za poremećaje napadaja. THC aktivira CB1 receptore, što može smanjiti ekscitabilnost i inhibirati otpuštanje neurotransmitera u nekim regijama mozga, dok CBD djeluje na CB1 i CB2 receptore te također utječe na serotonin i TRPV kanale za stabilizaciju neuronske aktivnosti. Kombinacija ovih kanabinoida može imati aditivni učinak, pri čemu CBD djeluje protiv euforije izazvane THC-om i pojačava ukupna antikonvulzivna svojstva. Neuroprotektivni i protuupalni učinci CBD-a dodatno doprinose njegovom potencijalu u smanjenju hiperaktivnosti neurona tijekom napadaja. Ova sinergija između THC-a i CBD-a može pomoći u upravljanju stanjima poput epilepsije, gdje je regulacija neuronske ekscitabilnosti ključna.

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