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Koji su kombinirani učinci THC-a i CBD-a na desenzibilizaciju kanabinoidnih receptora?

Koji su kombinirani učinci THC-a i CBD-a na desenzibilizaciju kanabinoidnih receptora? THC i CBD zajedno mogu utjecati na desenzibilizaciju kanabinoidnih receptora modulirajući aktivnost CB1 i CB2 receptora na različite načine. THC ima tendenciju da snažno aktivira CB1 receptore, što može dovesti do desenzibilizacije i tolerancije receptora tijekom vremena, smanjujući njegove terapeutske učinke. Međutim, pokazalo se da CBD djeluje kao negativni alosterički modulator CB1 receptora, potencijalno sprječavajući pretjeranu aktivaciju i usporavajući početak desenzibilizacije. Dodatno, CBD može promicati uravnoteženiju aktivnost receptora utječući na druge signalne putove koji su u interakciji s endokanabinoidnim sustavom. Kombinacija THC-a i CBD-a mogla bi stoga smanjiti vjerojatnost brze desenzibilizacije receptora, potencijalno povećavajući dugoročnu učinkovitost terapija koje se temelje na kanabinoidima.

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IMPORTANT: This information is NOT MEDICAL ADVICE and is only provided for general informational purposes only. Always first seek the advice of your doctor or a healthcare professional first before taking a CBD product or vitamin supplement if you are unsure. Statements regarding dietary supplements have not been evaluated by the FDA and are not intended to diagnose, treat, cure, or prevent any disease or health condition. No claims are intended to be made about the functions or ability of a CBD infused cosmetic product and/ or vitamin supplement to provide any specific health or wellness benefits. None of our CBD strips, patches or other CBD products are described, promoted or marketed as having any function not listed in the COSING Information Database. Any information provided here about CBD or any other ingredient and/ or product is strictly for general informational purposes and should not be interpreted as medical, therapeutic, or diagnostic advice. CBD products are not intended to diagnose, treat, cure, or prevent any disease or health condition. You are advised to always first consult with a doctor or a qualified healthcare professional before using any CBD product, particularly if you any of the following apply. DO NOT USE CBD IF PREGANT, BREAST FEEDING OR IF YOU HAVE A SERIOUS MEDICAL CONDITION. DO NOT USE IF PACKAGING HAS BEEN OPENED DURING SHIPPING. DISCONTINUE USE IF ANY ADVERSE REACTION OR SYMPTOM OCCURS. CONTACT A DOCTOR IF REACTION OR SYMPTOM CONTINUES. FOR ADULTS ONLY. STORE OUT OF REACH OF CHILDREN.