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How do the polarity and size of cannabinoid molecules impact their diffusion rate through the skin when applied via transdermal patches?

How do the polarity and size of cannabinoid molecules impact their diffusion rate through the skin when applied via transdermal patches? The polarity and size of cannabinoid molecules significantly affect their ability to diffuse through the skin’s lipid-rich barrier. Non-polar molecules, like CBG, tend to pass through the skin more easily than polar molecules like CBD, which may require the use of penetration enhancers. Smaller molecules generally diffuse faster through the skin layers, while larger molecules may be absorbed more slowly. Optimizing the formulation based on the cannabinoids’ properties can improve transdermal delivery efficiency.

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