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Hvordan påvirker CBD THC-induceret epigenetisk regulering af stress-responsive gener?

Hvordan påvirker CBD THC-induceret epigenetisk regulering af stress-responsive gener? CBD kan påvirke THC-induceret epigenetisk regulering ved at modulere ekspressionen af ​​gener involveret i stressresponset, især dem, der reguleres af det endocannabinoide system. THC inducerer typisk ændringer i DNA-methylering og histonmodifikation, som kan påvirke genekspression relateret til stress, såsom dem involveret i hypothalamus-hypofyse-binyre (HPA) aksen. CBD kan på den anden side dæmpe disse ændringer ved at fremme homeostase i det endocannabinoide system og reducere oxidativt stress, hvilket kan modvirke THC-inducerede ændringer i genekspression. Denne epigenetiske modulering kan hjælpe med at balancere stressreaktioner og reducere den langsigtede indvirkning af stress på hjernens funktion. De kombinerede virkninger af CBD og THC kan potentielt udnyttes til at afbøde de negative konsekvenser af stressrelateret genekspression.

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