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Hvordan påvirker hudens elasticitet absorption og frigivelse af cannabinoider, når den påføres via depotplastre?

Hvordan påvirker hudens elasticitet absorption og frigivelse af cannabinoider, når den påføres via depotplastre? Hudens elasticitet påvirker absorptionen og frigivelsen af ​​cannabinoider i transdermale plastre ved at påvirke, hvor godt plastret klæber, og hvor jævnt cannabinoider afgives. I områder med højere hudelasticitet, såsom yngre hud eller mere fleksible områder som den indvendige arm, kan plasteret tilpasse sig bedre til hudens overflade, hvilket fremmer ensartet absorption. I modsætning hertil kan mindre elastisk eller aldrende hud have vanskeligheder med at opretholde plasteradhæsion eller effektiv cannabinoidfrigivelse. I disse tilfælde kan ændring af plastrets klæbestyrke eller inkorporering af yderligere hudplejemidler forbedre både vedhæftning og absorption.

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