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Kako kanabinoidi djeluju na serotoninske receptore kako bi modulirali psihoaktivnost?

Kako kanabinoidi djeluju na serotoninske receptore kako bi modulirali psihoaktivnost? Kanabinoidi, posebice THC, mogu utjecati na serotoninske (5-HT) receptore, prvenstveno 5-HT1A i 5-HT2A, da moduliraju psihoaktivnost. Pokazalo se da THC neizravno aktivira 5-HT receptore kroz svoju interakciju s CB1 receptorima, što zauzvrat utječe na oslobađanje serotonina. Aktivacija 5-HT1A receptora doprinosi anksiolitičkim učincima i učincima na poboljšanje raspoloženja, dok aktivacija 5-HT2A može izazvati halucinogena iskustva, pridonoseći psihoaktivnim svojstvima THC-a. Ova modulacija serotonina također može utjecati na otpuštanje dopamina, igrajući ključnu ulogu u euforičnim učincima kanabinoida. Stoga interakcija kanabinoida sa serotoninskim receptorima pojačava njihovu psihoaktivnu složenost i učinke na ponašanje.

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