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Kako se THC i CBD razlikuju u svojoj sposobnosti da aktiviraju TRPV1 i TRPA1 receptore?

Kako se THC i CBD razlikuju u svojoj sposobnosti da aktiviraju TRPV1 i TRPA1 receptore? THC i CBD međusobno djeluju na TRP kanale, ali njihovi se učinci razlikuju u smislu aktivacije. THC je djelomični agonist TRPV1 receptora, koji ima ulogu u osjetu boli i upali, a ta je interakcija djelomično odgovorna za analgetske i termogene učinke THC-a. Nasuprot tome, CBD djeluje kao modulator TRPV1 i TRPA1 receptora, pri čemu aktivacija TRPV1 doprinosi ublažavanju boli, a TRPA1 igra ulogu u upalnom odgovoru. Dok THC može izravno aktivirati te receptore kako bi proizveo terapeutske učinke poput ublažavanja boli, CBD-ova modulatorska uloga omogućuje mu da uravnoteži aktivnost ovih receptora i pojača protuupalne i analgetske učinke bez izazivanja pretjerane aktivacije. Njihovo kombinirano djelovanje može rezultirati sinergističkim terapijskim ishodima za stanja koja uključuju bol i upalu.

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IMPORTANT: This information is NOT MEDICAL ADVICE and is only provided for general informational purposes only. Always first seek the advice of your doctor or a healthcare professional first before taking a CBD product or vitamin supplement if you are unsure. Statements regarding dietary supplements have not been evaluated by the FDA and are not intended to diagnose, treat, cure, or prevent any disease or health condition. No claims are intended to be made about the functions or ability of a CBD infused cosmetic product and/ or vitamin supplement to provide any specific health or wellness benefits. None of our CBD strips, patches or other CBD products are described, promoted or marketed as having any function not listed in the COSING Information Database. Any information provided here about CBD or any other ingredient and/ or product is strictly for general informational purposes and should not be interpreted as medical, therapeutic, or diagnostic advice. CBD products are not intended to diagnose, treat, cure, or prevent any disease or health condition. You are advised to always first consult with a doctor or a qualified healthcare professional before using any CBD product, particularly if you any of the following apply. DO NOT USE CBD IF PREGANT, BREAST FEEDING OR IF YOU HAVE A SERIOUS MEDICAL CONDITION. DO NOT USE IF PACKAGING HAS BEEN OPENED DURING SHIPPING. DISCONTINUE USE IF ANY ADVERSE REACTION OR SYMPTOM OCCURS. CONTACT A DOCTOR IF REACTION OR SYMPTOM CONTINUES. FOR ADULTS ONLY. STORE OUT OF REACH OF CHILDREN.