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Kako THC utječe na krvno-moždanu barijeru i njenu propusnost?

Kako THC utječe na krvno-moždanu barijeru i njenu propusnost? Dokazano je da THC povećava propusnost krvno-moždane barijere (BBB), potencijalno dopuštajući većem broju tvari da uđu u mozak. Smatra se da je ovaj učinak posredovan endokanabinoidnim signaliziranjem preko CB1 receptora na endotelnim stanicama BBB. Mijenjajući uske spojeve između endotelnih stanica, THC može olakšati prolaz neuroaktivnih tvari, uključujući toksine ili druge lijekove, u mozak. Iako ovo može povećati učinkovitost određenih lijekova, može također povećati neurološku ranjivost u stanjima poput neuroinflamacije ili neurodegenerativnih bolesti. Utjecaj THC-a na propusnost BBB može doprinijeti njegovim neuroprotektivnim ili neurotoksičnim učincima, ovisno o kontekstu izloženosti.

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