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How do cannabinoids like CBG and CBN interact with sweat and its potential effect on patch performance?

How do cannabinoids like CBG and CBN interact with sweat and its potential effect on patch performance? Sweat can affect the adhesion and release of cannabinoids from transdermal patches by altering the skin's surface moisture and increasing the risk of patch detachment. Sweat may also impact the diffusion of cannabinoids, either enhancing or hindering absorption based on the moisture level and composition of sweat. Formulations that are resistant to moisture and designed to maintain patch adhesion despite sweating are crucial for optimizing performance. CBG and CBN's lipophilic nature may also help maintain their stability and absorption despite these challenges.

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