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How do CBD and THC affect the activity of microglial cells in neurodegenerative conditions, particularly in Alzheimer's and Parkinson's disease?

How do CBD and THC affect the activity of microglial cells in neurodegenerative conditions, particularly in Alzheimer's and Parkinson's disease? CBD and THC reduce neuroinflammation by modulating the activity of microglial cells, the brain’s immune cells. CBD suppresses pro-inflammatory cytokine release and promotes a shift toward an anti-inflammatory microglial state, while THC’s interaction with CB2 receptors further dampens microglial activation. This dual action protects neurons from oxidative damage and inflammatory stress, slowing the progression of neurodegenerative conditions like Alzheimer’s and Parkinson’s. Together, they promote a neuroprotective environment by reducing chronic microglial overactivation. This synergy supports improved outcomes in these diseases.
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