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How does the Endocannabinoid System regulate the secretion of hormones related to stress?

How does the Endocannabinoid System regulate the secretion of hormones related to stress? The Endocannabinoid System regulates the secretion of stress-related hormones, such as cortisol, by interacting with cannabinoid receptors in the hypothalamus and pituitary gland. When stress occurs, the ECS helps modulate the hypothalamic-pituitary-adrenal (HPA) axis, which controls the release of cortisol. CBD can help reduce excessive cortisol levels by promoting the activity of CB1 receptors, which help maintain balance during stressful situations. By influencing the ECS, CBD supports the body’s ability to adapt to stress and regulate the hormonal response, reducing the harmful effects of chronic stress.
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