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How does the molecular weight of cannabinoid isolates affect their ability to diffuse through the skin’s layers?

How does the molecular weight of cannabinoid isolates affect their ability to diffuse through the skin’s layers? The molecular weight of cannabinoid isolates significantly influences their ability to diffuse through the skin's layers, with larger molecules generally having slower diffusion rates. Cannabinoids with lower molecular weights, such as CBD, tend to penetrate the skin more easily than larger molecules like CBG or CBN. To optimize absorption, formulations can be adjusted to either enhance the permeability of the skin or modify the cannabinoids’ molecular size. Using penetration enhancers or incorporating the cannabinoids into liposomes can also improve their diffusion rate.

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