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What scientific evidence supports the use of cannabinoids in treating nausea and vomiting associated with chemotherapy?

What scientific evidence supports the use of cannabinoids in treating nausea and vomiting associated with chemotherapy? Scientific evidence supports the use of cannabinoids in treating chemotherapy-induced nausea and vomiting (CINV), with several studies demonstrating their efficacy in this context. Clinical trials have shown that cannabinoids, particularly THC and CBD, can significantly reduce the severity and frequency of CINV in patients undergoing chemotherapy, leading to improved patient comfort and quality of life. For example, a meta-analysis found that cannabinoids were effective in treating CINV, especially in patients who did not respond adequately to conventional antiemetics. The mechanisms through which cannabinoids exert their antiemetic effects involve modulation of the endocannabinoid system and interactions with serotonin receptors, further validating their use in CINV management (Rocha et al., 2020).
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