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Miten delta-9-THC vaikuttaa endokannabinoidijärjestelmään?

Miten delta-9-THC vaikuttaa endokannabinoidijärjestelmään? Delta-9-THC on vuorovaikutuksessa endokannabinoidijärjestelmän (ECS) kanssa sitoutumalla CB1-reseptoreihin ensisijaisesti aivoissa ja keskushermostossa. Tämä vuorovaikutus aktivoi sarjan biologisia reaktioita, jotka muuttavat mielialaa, kiputuntemusta, muistia ja ruokahalua. ECS auttaa ylläpitämään homeostaasia kehossa, ja THC:n vuorovaikutus CB1-reseptorien kanssa voi häiritä normaaleja toimintoja ja tuottaa kannabikseen liittyvää "korkeaa". Delta-9-THC vaikuttaa epäsuorasti myös muiden endokannabinoidien, kuten anandamidin, toimintaan ja tehostaa niiden vaikutuksia. Vuorovaikutuksessa sekä CB1- että CB2-reseptorien kanssa THC voi myös vaikuttaa immuunijärjestelmään ja tulehdukseen.

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