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Hoe beïnvloeden endocannabinoïden de reactie van het lichaam op stress via het endocannabinoïde systeem?

Hoe beïnvloeden endocannabinoïden de stressreactie van het lichaam via het endocannabinoïdesysteem? Endocannabinoïden spelen een cruciale rol in de stressreactie van het lichaam door de afgifte van stresshormonen te reguleren en de emotionele balans te behouden. Via het endocannabinoïdesysteem binden endocannabinoïden zoals anandamide en 2-AG zich aan CB1- en CB2-receptoren in de hersenen en perifere weefsels. Dit helpt bij het moduleren van de activering van de hypothalamus-hypofyse-bijnieras (HPA-as), die verantwoordelijk is voor de afgifte van stresshormonen. Endocannabinoïden beïnvloeden ook stemmings-, angst- en vreesreacties, bevorderen ontspanning en verminderen stressgerelateerde ontstekingen. Samen helpen ze het lichaam zich aan te passen aan stress en de emotionele balans te behouden.
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