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Kako kanabinoidi utječu na sustav nagrađivanja da pojačaju ili umanje psihoaktivnost?

Kako kanabinoidi utječu na sustav nagrađivanja da pojačaju ili umanje psihoaktivnost? Kanabinoidi, posebno THC, utječu na moždani sustav nagrađivanja u interakciji s dopaminskim putevima i CB1 receptorima u regijama kao što su nucleus accumbens i ventralno tegmentalno područje. THC povećava otpuštanje dopamina, što dovodi do osjećaja euforije i nagrađivanja, što doprinosi psihoaktivnom iskustvu. Međutim, pretjerana aktivacija ovog sustava može dovesti do ovisnosti i tolerancije, smanjujući korisne učinke tijekom vremena. CBD ima složeniji odnos sa sustavom nagrađivanja, često smanjujući psihoaktivne učinke THC-a dok promiče neuroprotektivna svojstva i svojstva protiv ovisnosti. Utjecaj kanabinoida na sustav nagrađivanja središnji je kako za poboljšanje psihoaktivnosti tako i za potencijal ovisnosti i tolerancije.

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