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Kako kronična uporaba THC-a utječe na gustoću i signalizaciju CB1 receptora?

Kako kronična uporaba THC-a utječe na gustoću i signalizaciju CB1 receptora? Kronična uporaba THC-a može dovesti do regulacije receptora CB1, što rezultira smanjenom gustoćom receptora i signaliziranjem tijekom vremena. Ova desenzibilizacija endokanabinoidnog sustava može umanjiti psihoaktivne učinke THC-a, što dovodi do tolerancije i potrebe za višim dozama za postizanje istog učinka. Dodatno, kronična uporaba THC-a može narušiti povratnu regulaciju ECS-a, mijenjajući ravnotežu endokanabinoida i smanjujući sposobnost sustava da odgovori na prirodne fluktuacije. Ovaj je fenomen ključan za razvoj tolerancije na kanabinoide i može utjecati na ukupne terapijske i psihoaktivne ishode dugotrajne uporabe kanabisa. Razumijevanje ovog procesa važno je za upravljanje dugotrajnom uporabom kanabisa i sprječavanje ovisnosti.

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