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Kako THC i CBD različito utječu na intracelularnu signalizaciju kalcija?

Kako THC i CBD različito utječu na intracelularnu signalizaciju kalcija? THC i CBD utječu na intracelularnu signalizaciju kalcija kroz različite mehanizme. THC, primarno svojom aktivacijom CB1 receptora, može povećati unutarstanične razine kalcija u neuronima narušavanjem homeostaze kalcija, što može dovesti do neurotoksičnosti i promjene sinaptičke funkcije. Nasuprot tome, CBD ima modulirajući učinak na signaliziranje kalcija, djelujući preko TRPV1 i drugih ionskih kanala kako bi stabilizirao dotok kalcija i smanjio ekscitotoksičnost. Dok THC može potaknuti povećanje intracelularnog kalcija u određenim uvjetima, djelovanje CBD-a općenito pomaže uravnotežiti razine kalcija, štiteći tako neurone od prekomjerne stimulacije i oštećenja stanica. Ovaj diferencijalni učinak igra ulogu u njihovim ukupnim neuroprotektivnim i neurotoksičnim svojstvima.

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