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Kako THC utječe na signalne putove unutarstaničnog kalcija?

Kako THC utječe na signalne putove unutarstaničnog kalcija? THC utječe na intracelularnu signalizaciju kalcija prvenstveno kroz aktivaciju CB1 receptora na presinaptičkim neuronima. Ova aktivacija dovodi do smanjenog priljeva kalcija, inhibirajući otpuštanje neurotransmitera poput glutamata i GABA. Ovaj mehanizam pridonosi modulaciji sinaptičkog prijenosa, utječući na procese kao što su pamćenje, bol i regulacija raspoloženja. Osim toga, THC može utjecati na puteve posredovane kalcijem koji utječu na ekspresiju gena i staničnu signalizaciju, što može doprinijeti njegovim dugoročnim učincima na neuroplastičnost. Prekid signalizacije kalcija putem THC-a također može igrati ulogu u kognitivnim oštećenjima povezanim s uporabom kanabisa.

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