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Koji su kombinirani učinci THC-a i CBD-a na neurogenezu u hipokampusu?

Koji su kombinirani učinci THC-a i CBD-a na neurogenezu u hipokampusu? THC i CBD imaju različite učinke na neurogenezu u hipokampusu, pri čemu CBD pokazuje potencijal da pojača proces, dok ga THC može inhibirati. Pokazalo se da CBD potiče neurogenezu kroz svoju interakciju s CB2 receptorima i TRPV1 receptorima, pomažući u stimulaciji neuralnih matičnih stanica i promicanju rasta novih neurona. S druge strane, interakcija THC-a s CB1 receptorima može potisnuti neurogenezu odraslih u hipokampusu, vjerojatno kroz inhibiciju neuralnih čimbenika rasta posredovanu kanabinoidnim receptorima. Međutim, kada se kombiniraju, THC i CBD mogu uravnotežiti međusobne učinke, pri čemu CBD štiti od inhibicije neurogeneze izazvane THC-om. Ovo sugerira da bi kombinacija THC-CBD mogla promicati zdravu neuroplastičnost i funkciju hipokampusa, osobito u kontekstima poput neurodegenerativnih bolesti.

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