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Koji su rizici ovisnosti o THC-u i odvikavanja te kako se oni biokemijski manifestiraju?

Koji su rizici ovisnosti o THC-u i odvikavanja te kako se oni biokemijski manifestiraju? Ovisnost o THC-u javlja se zbog neuroadaptivnih promjena u moždanom sustavu nagrađivanja, osobito kroz regulaciju CB1 receptora. Smatra se da simptomi apstinencije, poput razdražljivosti, poremećaja spavanja i tjeskobe, proizlaze iz pokušaja mozga da uspostavi ravnotežu u nedostatku THC-a. Biokemijski, to uključuje promjene u oslobađanju dopamina i endokanabinoidnom tonusu. Kronična uporaba mijenja ekspresiju različitih neurotransmiterskih sustava, uključujući GABA i glutamat, što može doprinijeti disregulaciji raspoloženja tijekom odvikavanja. Ove biokemijske promjene čine izazov za pojedince da prestanu pušiti, što dovodi do recidiva i produljene ovisnosti.

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