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Come interagisce il THC con i recettori non cannabinoidi, come GPR55 e TRPV1?

Come interagisce il THC con i recettori non cannabinoidi, come GPR55 e TRPV1? Il THC interagisce anche con GPR55, un recettore accoppiato alle proteine ​​G coinvolto nella modulazione del dolore, dell'infiammazione e del metabolismo osseo. L'attivazione del GPR55 da parte del THC può amplificarne gli effetti analgesici, ma il ruolo esatto di questo recettore negli effetti psicoattivi del THC è ancora in fase di studio. Inoltre, il THC si lega ai recettori TRPV1, che sono coinvolti nella sensazione del dolore, nella termoregolazione e nell'infiammazione. Attraverso l’attivazione di TRPV1, il THC può produrre analgesia e ridurre l’infiammazione. Queste interazioni possono aiutare a spiegare gli effetti terapeutici più ampi del THC oltre la sua azione primaria sul sistema endocannabinoide.

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